The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
预测分子量
38 kDa
GeneID
5571
Uniprot
P54619
Isotype
IgG
标记类型
Un-conjugated
产品别名
AMPKG
Western blot detection of AMPK gamma 1 in Hela,A549,HL-60,U20S cell lysates using AMPK gamma 1 antibody(1:1000 diluted).
货号: RMA02180
AMPK gamma 1 Recombinant Rabbit mAb
反应种属:
Human
应用:
FCICC/IFIHCIPWB
¥ 1280
/ 50μl
库存充足
50μl100μl
产品详情
产品特性
反应种属
Human
应用
FCICC/IFIHCIPWB
纯化方式
Affinity Purification
实际分子量
38 kDa
免疫源
A synthetic peptide of human AMPK gamma 1
来源
Rabbit
克隆性
Monoclonal
Background
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]