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KCTD21 Rabbit pAb
Cat Number: DPA03672
KCTD21 Rabbit pAb
Applications:
WB,FC
Species Reactivity:
Human, Mouse, Rat
$ 169
/ 50ul
In Stock
50ul100ul
Description
Recommended Dilution
Product Features
Applications
WB,FC
GeneID
283219
MW
30 kDa
Uniprot
Q4G0X4
Purification method
Affinity Purification
Conjugate
Un-conjugated
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Immunogen
Recombinant protein of human KCTD21
Calculated molecular weight
30 kDa
Background
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
Alias
KCASH2
Cat Number: DPA03672
KCTD21 Rabbit pAb
Applications:
WB,FC
Species Reactivity:
Human, Mouse, Rat
$ 169
/ 50ul
In Stock
50ul100ul
Description
Recommended Dilution
Product Features
Applications
WB,FC
GeneID
283219
MW
30 kDa
Uniprot
Q4G0X4
Purification method
Affinity Purification
Conjugate
Un-conjugated
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Immunogen
Recombinant protein of human KCTD21
Calculated molecular weight
30 kDa
Background
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
Alias
KCASH2
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