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TRIM56 Rabbit pAb
货号: DPA02910
TRIM56 Rabbit pAb
反应种属:
Human
应用:
FCICC/IFIHCWB
¥ 960
/ 50μl
库存充足
50μl100μl
产品详情
推荐稀释比
产品特性
反应种属
Human
应用
FCICC/IFIHCWB
Uniprot
Q9BRZ2
GeneID
81844
Isotype
IgG
Background
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
预测分子量
82 kDa
分子量
82 kDa
纯化方式
Affinity Purification
标记类型
Un-conjugated
克隆性
Polyclonal
来源
Rabbit
免疫源
A synthetic peptide of human TRIM56
产品别名
RNF109
货号: DPA02910
TRIM56 Rabbit pAb
反应种属:
Human
应用:
FCICC/IFIHCWB
¥ 960
/ 50μl
库存充足
50μl100μl
产品详情
推荐稀释比
产品特性
反应种属
Human
应用
FCICC/IFIHCWB
Uniprot
Q9BRZ2
GeneID
81844
Isotype
IgG
Background
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
预测分子量
82 kDa
分子量
82 kDa
纯化方式
Affinity Purification
标记类型
Un-conjugated
克隆性
Polyclonal
来源
Rabbit
免疫源
A synthetic peptide of human TRIM56
产品别名
RNF109
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